Institut Pasteur of Shanghai, CAS
The ecotypes of Helicobacter pylori
Title: The ecotypes of Helicobacter pylori
Institut Pasteur of Shanghai, CAS
Daniel FALUSH is now the Principle Investigator and Professor in Institute Pasteur Shanghai, Chinese Academy of Sciences. He majored in Mathematical Tripos in University of Cambridge for his bachelor degree and obtained his PhD degree from Department of Biology, University College London. His specific biological research focus is to understand the causes and consequences of genetic variation within highly recombining species such as Helicobacter pylori and Vibrio parahaemolyticus from historical, functional, medical, ecological and evolutionary perspectives.
His most substantial research achievement has been the development of in silico chromosome painting, which uses patterns of haplotype sharing to infer fine-scale patterns of relationship and recent admixture history of populations. The core of the work is summarized in three publications: (1) describes the approach and its application to detect fine-scale population structure, (2) develops the methods for inference of recent admixture history and (3) showcases that with appropriate data, the methods can be applied to reconstruct the history of particular groups in unprecedented detail.
Prof. Daniel's achievements are published in Science, Nature, eLife, Molecular Biology and Evolution and many other jounals. He has been interviewed about his research in the New York Times, Daily Telegraph, Daily Mail and by John Simpson on the Today Program on BBC Radio 4. He is also becoming more active in science communication with my colleagues, for example in his widely read article, “A tutorial on how (not) to over-interpret STRUCTURE/ADMIXTURE barplots”. He has co-authored 21 papers with his former doctoral student Xavier Didelot, recently appointed as a full Professor at University of Warwick.
Scientific mentoring outside the conventional group structure includes with Dan Lawson and Garrett Hellenthal worked with Prof. Daniel on developing methods for chromosome painting and now both have Henry Dale Wellcome Trust Fellowships developing that work as well as permanent positions in University of Bristol and UCL. Prof. Daniel also has long term projects working with Kaisa Thorell at University of Gothenberg and Koji Yahara at National Institute of Infectious Diseases, Tokyo on Helicobacter pylori genomics, with Yujun Cui at the Institute for Microbiology and Epidemiology, Beijing on Vibrio parahaemolyticus genomics.
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